Symposium Sessions
Day 1, June 10（Wed.） 14:26-14:44 Room C (4F 413)
- 1C-S1-1426
Lipidomics uncovers the therapeutic potential of traditional Korean medicine in age-related diseases
(KIOM)
oJeeyoun Jung
Lipidomic remodeling has recently emerged as a key determinant of the aging process, particularly through its influence on mitochondrial function and cellular metabolism. Traditional herbal medicines have long been recognized for their potential to promote longevity and alleviate age-related disorders. Palmijihwang-tang (PM), a widely used traditional herbal medicine, has been reported to exert protective effects against aging-related pathologies, particularly kidney dysfunction.
In this study, we employed lipidomics to investigate the molecular mechanisms underlying the geroprotective effects of PM. Comprehensive lipidomic profiling combined with DESI-based spatial lipidomics revealed that PM treatment induces significant remodeling of lipid metabolic pathways associated with aging and renal dysfunction. Notably, PM modulated phospholipid metabolism in an aging model. Furthermore, spatial multi-omics identified a PM-derived bioactive compound responsible for attenuating kidney aging by regulating the composition of cardiolipin, a key phospholipid of the mitochondrial inner membrane that is essential for mitochondrial lipid homeostasis.
Together, these findings demonstrate that integrating mass spectrometry–driven lipidomics with spatial multi-omics enables the identification of bioactive compounds and molecular mechanisms underlying the geroprotective effects of traditional herbal medicines.