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Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-PM-03
Mass Spectrometry Imaging of Crude Drugs Using Transfer Plates
(1Kyushu Univ. Med. Sci., 2Hamamatsu Univ. Sch. Med., 3Preppers, 4Hamamatsu Photonics)
oHisahiro Kai1, Takumi Sakamoto2,3, Takamasa Ikeda4, Yutaka Takahashi2,3, Mitsutoshi Setou2,3
Crude drugs are medicines derived from plants, animals, or minerals (natural resources) that are dried after collection and subjected to simple processing as needed. Typically only a specific part of a natural resource is used as a crude drug. For instance, the Japanese Pharmacopoeia describes “Peony Root" as derived from the root of Paeonia lactiflora and “Moutan Bark" as derived from the root bark of Paeonia suffruticosa (Paeonia moutan). However, methods to effectively analyze the localization of natural resource constituents used as crude drugs are lacking. Here, we present a mass spectrometry imaging (MSI) method using transfer plates to determine the localization of various crude drug constituents. MSI enables visualization of the localization of molecules on the surface of planar samples such as biological tissue sections using m/z information obtained from mass spectrometry and has attracted attention in the fields of pharmacokinetic analysis and disease-related marker discovery research. However, some crude drug materials are difficult to slice. Therefore, we show here an example of MSI analysis of crude drugs using a transfer plate (Poropare) developed by Hamamatsu Photonics K.K.