| Timetable |
| Download Conference Program |
| Download All Abstracts |
| Zoom Access |
| Corporate Program |
Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-PM-45
Visualization of Tamoxifen Distribution and Sensitivity Assessment in Breast Cancer Tissues Using Imaging Mass Spectrometry
(1Kyoto Pref. Univ. Med., 2Shimadzu Corp.)
oChikage Kato1, Takushi Yamamoto1, Yasuto Naoi2
Understanding drug pharmacokinetics is essential for enhancing drug sensitivity and optimizing drug delivery in cancer therapy. This study employed imaging mass spectrometry (IMS) using MALDI-TOFMS to visualize the intratumoral distribution of tamoxifen (TAM) in breast cancer tissues. Fresh-frozen tissue samples from patients with hormone receptor-positive, HER2-negative breast cancer who underwent preoperative TAM treatment were analyzed. The TAM ion spectrum was successfully visualized across various histological subtypes, and TAM distribution was found to be significantly higher in cancerous regions than in stromal areas. Metabolite analysis of TAM revealed that its pharmacologically active metabolites could serve as potential biomarkers for drug sensitivity. Furthermore, UMAP clustering identified phospholipid clusters co-localized with tumor regions and TAM distribution, suggesting their potential as biomarkers for cancer diagnosis and sensitivity assessment. These findings highlight the potential of IMS-based visualization of intratumoral drug distribution as a novel metric for evaluating drug sensitivity in precision medicine.