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Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-PM-25
Benzophenone-type UV filters in the hair of Taiwanese Young Adults by SLE and SPE-based UHPLC–MS/MS
(NYCU)
oJiong-Heng Du, Yu-Fang Huang
Benzophenone (BP) and its derivatives (BPDs) are chemicals that can interfere with hormone action. The International Agency for Research on Cancer (IARC) has classified BP as a possible human carcinogen (Group 2B). BP occurs naturally in some foods and BPDs are commonly used as UV filters in food packaging inks and personal care products. This aim of this study was to establish a method for analyzing 10 BPDs (BP, BP-1, BP-2, BP-3, BP-8, 4-hydroxybenzophenone [4-OHBP], 2-hydroxybenzophenone [2-OHBP], 4-methylbenzophenone [4-MBP], methyl-2-benzoylbenzoate [M2BB], and 4-benzoylbiphenyl [PBZ]) in hair by solid-liquid extraction and solid-phase extraction coupled with ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
The method showed satisfactory linearity (R2 > 0.995) on the calibration curve from 0-100 ng/mL. The detection limit ranged from 0.02 to 0.43 ng/g.The limit of quantification ranged from 0.08 to 1.44 ng/g. The mean recovery (n=3) ranged from 88-155% at the level of 100 ng/mL. The intra- and inter-day precision ranged from 0.1 to 10.5% at the level of 50 ng/mL. The validated method was applied to the analysis of 36 hair samples collected from young adults in northern and central Taiwan.