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Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-AM-50
Molecular Mapping of the Formose Reaction via High-Resolution Mass Spectrometry
(1Univ. Osaka, 2Univ. Tokyo)
oHiroaki Nishijima1, Hiro Tabata1,2, Rika Miyake1, Shuji Nakanishi1
The formose reaction, an autocatalytic process converting formaldehyde to complex carbohydrate mixtures under alkaline conditions, has significant potential in artificial sugar synthesis. While previous studies have primarily focused on target carbohydrate products, the complete molecular characterization of the reaction mixture, including by-products, has received limited attention. This study employs Flow Injection Electrospray Ionization Time-of-Flight Mass Spectrometry (FI-ESI-TOF-MS) combined with molecular formula assignment and van Krevelen diagram visualization to characterize the broader spectrum of formose reaction products. Reaction mixtures using two different catalytic systems (NaOH and Ca(OH)₂) were sampled at various time points to monitor the evolution of the product distribution. Our analytical strategy provided a holistic view of the reaction's molecular landscape, enabling the identification of compounds beyond the traditional carbohydrate region and revealing multiple homologous series and molecular clusters. Time-course sampling revealed significant formation and evolution patterns differences between the two catalytic systems. These findings provide a more comprehensive molecular perspective on the Formose reaction, offering insights into sugar products and by-products. This expanded understanding of the reaction system complements traditional sugar-focused studies and may contribute to the development of more selective artificial sugar synthesis methods by elucidating by-product formation pathways.