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Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-AM-33
Integrative Analysis of Lipids in Plasma and Multiple Organs of MASH Mice Using LC/MS
(1Hokkaido Univ. Health sciences, 2Hokkaido Univ. GFR, 3Univ. Sapporo Health Sciences)
oNao Inoue1, Hsin-Jung Ho1, Siddabasave Gowda Bomme Gowda1,2, Miki Eguchi1, Minato Takeuchi1, Hitoshi Chiba3, Shu–ping Hui1
Metabolic dysfunction-associated steatohepatitis (MASH) is a type of fatty liver disease characterized by fat accumulation, hepatic inflammation, and fibrosis. There is an increasing interest in the crosstalk network between the liver and other organs in MASH. Here, we report the alteration of lipidomic profile in the liver, kidney, brain, and plasma in MASH model mice, using LTQ-Orbitrap LC-MS/MS. In comparison with control mice, MASH mice showed the increase of oxidized lipids in liver and kidney, and the increase of fatty acid 20:3n-6 and lysophosphatidic acid 20:0 in the brain, suggesting that the metabolic dysfunction in MASH led to systemic inflammation. Further, the lipid species involved in mitochondrial function decreased in the kidney of MASH mice, suggesting possible bioenergetic disorder. Interestingly, alkyl-ether-linked phosphatidylethanolamine (PE), known to exert anti-inflammatory action, decreased in both plasma and liver of MASH. To the best of our knowledge, there are few reports on the alteration of alkyl-ether-linked PE in MASH. The present observations might contribute to a comprehensive understanding of the process of onset/progression of MASH, and to identification of potential therapeutic targets for MASH.