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Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-AM-24
Development of a Rapid and Highly Sensitive Detection Method for Per- and Polyfluoroalkyl Substances Using the Isotope Dilution Method and Its Application in Evaluating the PFAS Levels in Chronic Kidney Disease Patients Before and After Oral Activate
(NYCU)
oYen-Erh Chen, Han-Hsing Tsou
Per- and polyfluorinated alkyl substances (PFAS) are environmental toxins that have long attracted international attention. They are highly stable and bioaccumulation in the environment. This study uses the isotope dilution method to establish a a rapid and highly sensitive PFAS detection method. research was conducted on ten representative PFAS (PFBS, PFHxS, PFOS, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA). Human blood samples were analyzed for PFAS using UPLC-MS/MS.
This method completes quantitative analysis within seven minutes and exhibits excellent linearity (r² > 0.995). Its limit of quantification range is 3-167 ng/mL, showing high sensitivity and good reproducibility.
Since PFAS can induce oxidative stress and thus affect kidney function, this study will further explore the relationship between PFAS and chronic kidney disease (n=100, stage 3-5). In the efficacy study of oral activated carbon capsules (case group/control group=50/50), the experimental group took oral pH-regulated activated carbon capsules (AC-134) three times a day for three months. Activated charcoal capsules are expected to improve renal function and reduce body PFAS concentrations in CKD.