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Poster Presentations
Day 3, June 24（Tue.）
Room P (Maesato East, Foyer, Ocean Wing)
- 3P-AM-20
Association between prenatal exposure to benzophenones and birth outcomes
(IEOHS, NYCU)
oWei-Hsuan Tu, Mei-Lien Chen, Yu-Fang Huang
Benzophenones (BPs) have been confirmed to be endocrine disrupting chemicals and have estrogenic and anti-androgenic properties. BPs are often added to sunscreens or cosmetics to serve as UV filters. This study aims to explore the association between prenatal exposure to benzophenones and birth outcomes in Taiwan Maternal Infant Cohort study (TMICs).
This study used liquid-liquid extraction and ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to determine urinary BPs metabolites of 95 pregnant women in the third trimester of pregnancy, including 2,4-Dihydroxybenzophenone (BP-1), 2,2',4,4'-Tetrahydroxybenzophenone (BP-2), Oxybenzone (BP-3), Dioxybenzone (BP-8), and 4-hydroxybenzophenone (4-OHBP). The detection limits, recovery rates , and precisions were between 0.03 and 0.11 ng/mL, between 96% and 110%, and ≦ 8%, respectively. The detection rate of BP-3 was 97% and concentrations ranged from 0.10 to 566.74 ng/mL. The average concentration was 11.35 ng/mL and geometric mean (GM) was 1.39 ng/mL. As for benzophenone (BP), solid-phased extraction was conducted for sample pre-treatment. The LOD and recovery rate was 0.1 ng/mL and 112.7 ng/mL, respectively. The concentrations ranged from 0.13 to 16.57 ng/mL and the GM was 3.66 ng/mL.
This study will further analyze the effects of gestational age and neonate birth outcomes, such as head circumference, chest circumference, height, weight, and Ponderal Index as a results of maternal exposure to benzophenones.