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Oral Sessions
Day 3, June 24（Tue.） 16:00-16:15
Room C (Top of Yaima)
- 3C-O3-1600
Two-Dimensional Imaging of ¹³C-Glucose Tracing in Metabolome Analysis Using DESI-TQ-MS
(Kyoto Univ.)
oYuki Sugiura
This study combined DESI with TQ-MS to perform IMS for central metabolic compounds. Pregnant mice were continuously administered 13C6-glucose, and SRM was used to selectively image 13C6-glucose and its metabolite isotopomers in fetal tissues. The method successfully visualized 13C6-labeled compounds in central metabolic pathways, which are difficult to detect with MALDI imaging, providing spatial distribution data. This system extends traditional LC-ESI-MS/MS metabolomics to two-dimensional imaging without modifying SRM settings, enabling high-sensitivity spatial analysis of metabolic pathways.