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Oral Sessions
Day 3, June 24（Tue.） 15:45-16:00
Room C (Top of Yaima)
- 3C-O3-1545
Integrated MS-based OMICs to Reveal Intercellular Communication Events in Plant Systemic Immunity
(Academia Sinica)
oYet-Ran Chen
Plants, as sessile organisms lacking mobile immune cells, rely on intricate chemical signals and molecular defenses to mount systemic immunity against pathogens and pests. While peptides are essential mediators of cell-cell communication, their roles in plant immunity remain poorly understood. To address this, we developed comprehensive mass spectrometry (MS)-based peptidomics techniques. Integrating peptidomics and metabolomics, we identified CAPEs, a novel and highly conserved cytokine family crucial for activating systemic immunity triggered by salicylic acid and early detection of pathogen. We also elucidated CAPE maturation from its precursor and demonstrated its essential role in systemic immunity. Further integrating proteomics and metabolomics, we identified the CAPE receptor (CAPER) and a downstream metabolite that amplify and propagate the defense signal. Our findings reveal how CAPE is produced and perceived, how it interacts with small metabolite signals to form a positive feedback loop, and how these amplified signals target specific cell types to drive systemic immunity. Additionally, our advanced metabolomics platform uncovered how CAPE promotes the production of secondary metabolites beneficial to human health. These discoveries provide promising strategies to enhance crop productivity and nutritional value while reducing reliance on agrochemicals.