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Oral Sessions
Day 3, June 24（Tue.） 14:25-14:40
Room C (Top of Yaima)
- 3C-O2-1425
Application of ultrasensitive mass spectrometry-based single cell proteomics to address individual cell response
(IMCB, A*STAR Singapore)
Tianyun Zhao, Maxine Lam, Hiromi Koh, oRadoslaw Sobota
Until recently, genomics technologies were dominant in the area of single cell omics research. Genomics success story was mostly related to signal amplification step which was not possible with other technologies. The recent technological progress in ultrasensitive mass spectrometry and related analytical areas, have increased the analytical depth of proteomics such that single cell analysis is now possible. Utilizing Bruker timsTOF-SCP platform with in-house manufactured tools, we have developed the pipeline which allows to study on the single level effect of pharmacological perturbation. Subsequently, we benchmarked our approach using kinase inhibitors, further validating its effectiveness.