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Oral Sessions
Day 3, June 24（Tue.） 12:10-12:25
Room C (Top of Yaima)
- 3C-O1-1210
Breath biomarkers for monitoring lipid peroxidation and ferroptosis in vivo
(Kyoto Univ.)
oYuta Matsuoka, Yuki Sugiura
Volatile organic compounds resulting from metabolic processes are released as biogas, and potentially can serve as noninvasive biomarkers of cellular metabolic health.
During ferroptosis, a form of cell death caused by lipid peroxidation (LPO), oxidized lipid fragments can be released as biogas. We identified volatile oxidized lipids (VOLs) produced and released by cells undergoing metal-dependent LPO.
Several identified VOLs were validated as ferroptosis markers in in vitro cultured cells, in vivo animal models, and in human breath. We find these VOLs specifically produced in the liver during ferroptosis, in model mice of metabolic dysfunction-associated steatohepatitis (MASH) and in the exhaled air from patients with MASH.
Our identification of specific VOLs released upon metal-dependent LPO, highlights their potential utilization as valuable markers for cells undergoing ferroptosis in vivo, which can be apply non-invasively to monitoring cellular health in humans.