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Oral Sessions
Day 3, June 24（Tue.） 11:25-11:40
Room C (Top of Yaima)
- 3C-O1-1125
RNA epitranscriptome in clinical diagnosis and beyond
(1Tohoku Univ. IDAC, 2Tohoku Univ. Pharm. Sci.)
oFan-Yan Wei1,2, Akiko Ogawa1,2
Recent advances in clinical mass spectrometry have illuminated the role of RNA modifications as potential biomarkers in extracellular fluids, opening new avenues for diagnosing and monitoring complex disorders. This presentation highlights our latest research, focusing on the measurement of RNA modifications in extracellular fluid and their translational implications for mitochondrial and inflammatory diseases. We demonstrate that distinct RNA modification signatures can be reliably detected in extracellular samples such as plasma and cerebrospinal fluid. Our findings reveal significant alterations in RNA modification profiles associated with mitochondrial dysfunction and inflammation, suggesting their utility as minimally invasive biomarkers for disease onset, progression, and therapeutic response. These insights not only enhance diagnostic precision but also contribute to understanding the pathological mechanisms underpinning these conditions. The study underscores the potential of reverse translational research—moving from clinical observation back to fundamental pathophysiological insights—to inform targeted treatment strategies. Overall, RNA modification profiling via mass spectrometry represents a promising diagnostic and prognostic approach, bridging clinical application and basic research in mitochondrial and inflammatory diseases.