| Timetable |
| Download Conference Program |
| Download All Abstracts |
| Zoom Access |
| Corporate Program |
Poster Presentations
Day 2, June 23（Mon.）
Room P (Maesato East, Foyer, Ocean Wing)
- 2P-PM-19
Application of Metal-free Column with InertMask technology in LC-MS/MS
(GL Sciences Inc.)
oNozomi Murayama, Masanori Motokawa, Mika Kano, Junichi Hashimoto
In recent years, the demand for reliable and highly sensitive analysis using LC-MS/MS has increased significantly. In the HPLC analysis of metal-adsorbing compounds, the influence of adsorption on the inner surface of the column hardware cannot be ignored when aiming for high sensitivity in LC-MS/MS analysis. InertMask (IM) is our new metal surface treatment, which forms an organic silicon oxide layer on a metal surface such as stainless steel. This IM technology is very effective for the piping parts of analyzers where metal-assignment adsorption of acidic and basic compounds is a concern. We developed a new metal-free stainless steel HPLC column: the IM Column. In LC-MS/MS analysis of peptide compounds, the IM Column reduces specific adsorption of analytes, particularly on the column hardware surface, leading to improved sensitivity and peak shape. In this report, we suggest that the use of the IM Column is one of the effective methods for the analysis of metal-adsorbing compounds in LC-MS/MS.