The 10th Asia-Oceania Mass Spectrometry Conference (AOMSC2025) - organized by the Mass Spectrometry Society of Japan

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Day 2, June 23(Mon.) 

Room P (Maesato East, Foyer, Ocean Wing)

  • 2P-CP-03

REVOLUTIONIZING TRANSLATIONAL RESEARCH: LARGE-SCALE TARGETED PRM PROTEOMICS ASSAYS ENABLED BY STELLAR MASS SPECTROMETER (MS)

(1Thermo Fisher Scientific, 2Thermo Fisher Scientific San Jose, 3Thermo Fisher Scientific Singapore)
Scott Peterman1, Qingling Li2, oNicole Zhang3

Targeted mass spectrometry assay development for biomarker validation is no simple task. Although, the alure of finding a conclusive biomarker to indicate the presence of disease seems simple and straightforward in the discovery phase, the verification step is a painstakingly costly process. While traditional methods of analyzing target proteins defer to immunological or affinity-based assays, they suffer from lack of specificity and sensitivity. This is of critical concern for potential low abundant biomarkers in highly complex biomatrices. Biomarker verification by Thermo ScientificTM StellarTM MS provides increased sensitivity, greater specificity and extended accuracy. Here, we showed a streamlined workflow from generating a Skyline file to select LC peaks, creating PRM methods, and exporting MS results for further analysis within 3-4 days.