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Plenary Lecture
Day 2, June 23(Mon.) 8:30-9:30
Room A (Maesato West), Room B (Maesato Center), Room C (Top of Yaima)
- 2-PL-0830
Exploiting the Mass Spectrometry Toolkit for Biomedical Discoveries and Clinical Translation
(Mayo Clinic)
oAkhilesh Pandey
New mass spectrometry instrumentation and automation are providing exciting opportunities for fresh approaches to biological and clinical problems. I will use examples from our laboratory to showcase technological improvements and applications to biological and clinical problems. I will describe our efforts to study congenital disorders of glycosylation, which are rare genetic diseases resulting from defects in the enzymatic addition of glycans to proteins and lipids. This has led to discovery of glycopeptides as novel biomarkers that for accurate diagnosis and therapeutic monitoring of patients. We are also using peptidomics to discover novel peptides including neuropeptides for which mass spectrometry is an ideal discovery tool. In this regard, I will highlight some of the accidental discoveries along this journey that are changing textbooks. I will describe the use of spatial proteomics through laser capture microdissection coupled to high sensitivity mass spectrometry for improving the diagnosis of certain tumors, identifying tumor subtypes and investigating Lewy bodies in Parkinson's disease. Through development of novel small molecule assays, I will illustrate how mass spectrometry can contribute to improving the diagnosis of rare genetic disorders. Finally, I will outline several MALDI mass spectrometry-based spatial imaging applications including glycan and lipid imaging and multiplexed antibody staining.