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Poster Presentations
Day 1, June 22（Sun.）
Room P (Maesato East, Foyer, Ocean Wing)
- 1P-PM-36
Ketogenic diet promotes muscular endurance by altering muscle fiber composition in gastrocnemius not soleus muscle
(1GILS National Defense Medical Center, 2PhD Program for CBDD Taipei Medical Univ., 3CBDD Taipei Medical Univ., 4GIMS National Defense Medical Center)
oCheng-Yi Ma1, Tsui-Chin Huang2,3, Hsin-Yi Chang4
Diet and exercise are common strategies for weight loss; however, the impact of weight-loss diets on exercise remains less explored. The high-fat, low-carbohydrate ketogenic diet (KD) has been proposed to enhance exercise performance in athletes, yet to a lesser extent in the obese population. This study aims to investigate the impact of KD on endurance exercise during weight-loss intervention. Diet-induced obese C57BL/6J mice were divided into three dietary groups: one group switched to a KD, another group remained on a high-fat diet as a negative control, and a third group switched to a standard chow diet as a positive control. Isobaric tandem mass tag-based quantitative proteomic analysis was conducted on liver, soleus and gastrocnemius muscles. Revealed that the gastrocnemius muscle and liver were more responsive to dietary changes. These tissues remodeled the mitochondrial electron transport chain complexes II and III to sustain ATP production (Complex V) during aerobic exercise. KD promoted the composition of type I muscle fibers in the gastrocnemius muscle, increasing proteins involved in fatty acid oxidation and oxidative phosphorylation, while limiting fatty acid synthesis.In conclusion, our findings suggest that KD can be an effective strategy for improving exercise capacity during weight loss in obese population.