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Poster Presentations
Day 1, June 22（Sun.）
Room P (Maesato East, Foyer, Ocean Wing)
- 1P-PM-30
Proteomic Profiling of Serum Extracellular Vesicles Reveals RARRES2 as a New Potential Biomarker for PCOS Detection
(1School of Nutrition and Health Sciences, TMU, 2Research Center of Nutritional Medicine, TMU, 3Graduate Institute of Cancer Biology and Drug Discovery, TMU, 4PhD Program for Cancer Molecular Biology and Drug Discovery, TMU, 5Graduate Institute of Medical Sciences, NDMC, 6Department of Research and Development, NDMC)
oJun Yi Chong1, Shih-Min Hsia1,2, Tsui-Chin Huang3,4, Hsin-Yi Chang5,6
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with a complex pathophysiology1). This study aims to characterize the extracellular vesicle (EV) proteome in the serum of PCOS patients to identify potential biomarkers and therapeutic targets. EVs were isolated from PCOS patients and healthy controls, and quantitative proteomic analysis was performed using isobaric tag labeling and LC-MS/MS. 19 proteins were found differentially expressed between the two groups, with IGF-I and RAA1 as the most significantly up- and downregulated protein respectively. Enrichment analysis found that complement and coagulation cascades was significantly downregulated, whereas proteins involved in haptoglobin/haemoglobin complex were upregulated. WGCNA identified gene modules associated with clinical traits, with functional enrichment analysis revealing two distinct clusters which involve in lipid regulation and immune activation respectively. Notably, RARRES2, also known as chemerin, was identified both in significant DEPs and the WGCNA module of interest. This study was the first to identify RARRES2 as an exosomal proteins that might play a role in the development of PCOS pathophysiology, providing new insights into the roles of exosomes in the disease.