ポスター発表
第3日 6月12日（水） P会場（多目的ホール・大会議室101＋102）P1会場（多目的ホール）・P2会場（会議室101＋102）
- 3P-41
酸素付着解離(OAD)を用いた生体組織中脂質のC=C位置異性体MSイメージング
(島津)
o中川薫・ 笠松郷志・ 竹下建悟・ 小林まなみ・ 高橋秀典
Lipids are essential biomolecules that function as signaling molecules, energy sources, and skin barriers, in addition to constituting cell membranes. These diverse physiological functions are supported by the structural diversity of lipids. In particular, the position of the double bond (C=C) in the lipid structure is an important factor that determines the physical properties of biomembranes, substrate selectivity in metabolic reactions, and physiological functions of signaling molecules. Chemical derivatization, ozone-induced dissociation (OzID), ultraviolet photodissociation (UVPD), or electron-induced dissociation (EID), and ion mobility have been reported as separation techniques for lipid isomers in MS imaging (MSI). In this study, we implement Oxygen Attachment Dissociation (OAD)1-3), a fragmentation method that specifically dissociates C=C, in MSI to demonstrate the utility of this approach.