演題概要

3P-13

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NanoESI-MS/MS測定を用いた材料選択における安定性評価

(東レリサーチセ)
^o李茜・ 日下田成・ 松田景子

Material selection significantly influences product performance and lifespan, necessitating a comprehensive examination of material properties for informed choices. While evaluation methods for materials are being established, there remain challenges in efficiently evaluating stability. In response, we have developed a stability evaluation method for unstable compounds by combining nanoESI, a highly soft ionization technique, with MS/MS measurements. In this study, we focused on biosensors monitoring NH₄⁺ levels in sweat under physical exertion, aiming to select ionophores with binding ions that have minimal impact on electrical properties. Using nanoESI-MS/MS, we conducted stability evaluations of the binding ions of Nonactin and TD19D6 with NH₄⁺. As a result, the stability of TD19D6-NH₄⁺ was estimated to be relatively high. Based on the result, this method is expected to provide guidelines for material selection across various fields.