演題概要

3P-05

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LC/MS用分離技術「真空示差イオンモビリティ分析装置」の性能向上

(島津)
^o洪暎淳・ 石井俊匡・ 前田裕樹・ 小河潔・ 古橋治

Differential mobility spectrometry (DMS) separates ions based on the nonlinear change in their mobilities between high to low electric fields, which are elicited in a field asymmetric waveform applied to electrodes. This nonlinear change in ion mobility has less dependence on a molecular weight, and thus DMS can be useful for separation of structural isomers and isobars. The mobility coefficient in DMS can be expanded by nonlinear terms of E/N (E: Electric field strength, N: Gas density). Therefore, higher E/N gives greater change in mobility and results in higher resolution. We have developed vacuum DMS, which reduces gas density N and gives higher E/N than conventional atmospheric DMS. We showed the examples of analyses using LC-vacuum DMS-MS at this conference last year. Now, we found that separation ability in vacuum DMS can be improved by optimizing conditions of the electric field. Here we show the details of the improvement with analysis examples.