ランチョンセミナー
第3日 6月12日（水） 12:00～13:00 A会場（中ホール300）
- 3A-L-1200
三連四重極質量分析計による超高感度イメージング質量分析〜生理活性分子を自在にイメージングできる時代の到来〜
(京大がん免センター)
o杉浦悠毅
Imaging mass spectrometry has been developed as a method to visualize the localization of bioactive molecules. The main hurdle is the low abundance of such signaling molecules. Prostaglandins, for example, are present in concentrations as low as picograms per milligram tissue weight, requiring high sensitivity.
Triple quadrupole instruments capable of imaging can target these low abundant molecules by monitoring the generation of specific fragment ions and integrating the signal over tens of milliseconds. With these features, DESI-TQ-MS visualized the localization of monoamines in the brain with high spatial resolution without derivatization or matrix application. In addition, the previously difficult visualization of prostaglandins in the brain was achieved.
Keywords: Imaging mass spectrometry, bioactive molecules, DESI