ポスター発表
第2日 6月11日（火） P会場（多目的ホール・大会議室101＋102）P1会場（多目的ホール）・P2会場（会議室101＋102）
- 2P-18
DESI TQおよびDESI Q-Tof質量分析計による薬物とその代謝物のイメージング分析
(1日本ウォーターズ・ 2ウォーターズ)
o鈴木悦子1・ Paxton, Thanai1・ Claude, Emmanuelle2・ Munjoma, Naysha2・ Ballantyne, Joanne2
Typically, DMPK studies are performed using LC/MS with ESI of biofluids and tissues that have been homogenized and therefore the molecular localization is lost. DESI mass spectrometry imaging (MSI) allows the determination of small molecule distributions directly from tissue, such as pharmaceutical compounds and their metabolites as well as endogenous molecules.
Here a DESI source mounted on either a high-resolution Q-Tof or a TQ MS were used in a multi-step workflow allowing the localization of Gefitinib and its metabolites in liver, with timed collection, to monitor DMPK and the metabolism over time, directly from tissue section.