基盤セッション
第1日 6月10日（月） 15:27～15:45 C会場（中会議室201）
- 1C-O1-1527
ヒト血漿の質量分析マルチオミクス：喫煙者の推定と特異的タンパク質の検出
(ツムラ)
o平本昌志・ 紺野邦裕・ 土屋直子・ 松本隆志
Mass spectrometry based multi-omics for understanding the molecules which contribute to the pharmacological actions of Japanese traditional Kampo medicine was constructed, and its performance was evaluated using commercial plasma of twenty-four healthy human subjects. Non-targeted metabolomics detected Cotinine in multiple samples and discriminated presumptive smokers. Plasma EVs proteomics revealed that increased expression of two extracellular matrix component proteins, each of them may be associated with asthma and cardiomyopathy, was observed in the group which Cotinine was detected.