演題概要

特別講演

第2日 5月19日(木) 16:00~16:45 A会場(オービットホール)

生体リズムを基盤にした創薬・育薬

(九大院薬)
o大戸茂弘

In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nuclei; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 hr cycles. Clock genes, identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior, regulate several disease such as cancer, metabolic syndrome and sleep etc. The knowledge of clock genes should be applied for the clinical practice. Identification of a rhythmic marker for selecting dosing time will lead to improved progress and diffusion of chronopharmacotherapy. To monitor the rhythmic marker such as clock genes it may be useful to choose the most appropriate time of day for administration of drugs that may increase their therapeutic effects and/or reduce their side effects. Furthermore, to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs appears to lead to the new concept of chronopharmacotherapy. This presentation is to provide an overview of the regulatory system of biological rhythm from viewpoints of clock genes and the possibility of pharmacotherapy based on clock genes.