Oral Sessions (Day1, Day2, Day3)
Poster Presentations
(Day1, Day2, Day3)
Oral Sessions
- Day 3, May 17（Fri.） 16:05-16:25 Room D (202)
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3D-O2-1605 PDF
Frequency Division Multiplex LC-MS for Simultaneous Analyses
Multiplex high-performance liquid chromatograph-mass spectrometer (HPLC-MS), in which multiple HPLCs and one MS are hyphenated, is an approach for high throughput analysis in HPLC-MS. A general multiplex HPLC-MS employs a column-switching technology, and only one HPLC is connected to an MS at a time. In the present study, we propose a novel multiplex HPLC-MS system for simultaneous HPLC-MS analyses. In this study, multiple HPLCs are hyphenated with one MS without a column-switching mechanism, and a mixed-chromatogram is observed in MS. Here, we employ a frequency division multiplexing (FDM) technique used in communication engineering to extract any chromatogram from the mixed-chromatogram. When the modulator is set between each ion source and the MS, each modulator blocks each sample stream with an individual frequency. The use of ion gate modulators lead to the extraction and restoration of each chromatogram from the mixed-chromatogram without interference.