日本質量分析学会 第67回質量分析総合討論会

Program

Timetable

May be modified after the paper submission deadline.

Timetable(PDF 48KB)
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Plenary Lectures

■Plenary Lecture 1
Prof. Dr. Joost A. de Gouw (Univ. Colorado Boulder)
■Plenary Lecture 2
Prof. Dr. Martin F. Jarrold (Indiana Univ.)
■Plenary Lecture 3
Prof. Dr. Yasumitsu Ogura (Chiba Univ.)

Oral Sessions

■Title
Metallomics
■Organizer
Takafumi Hirata (Univ. Tokyo) / Tomonari Umemura (Tokyo Univ. Pharm. Life Sci.)
■Keynote
Akitoshi Okino (Tokyo Tech.)
■Scope
For the most creatures and plants, metal elements play important roles to regulate the physiological functions. Other major- to minor-essential metal elements, such as K, Na, Mg, and Ca are the essential nutrients for regulating the osmotic pressure, neurotransmission or muscle contractions. Moreover, trace-metal elements, such as Fe, Cu, Zn, or Mo are responsible for the activation and functionalization of metalloproteins or metalloenzymes as a cofactor. Incorporation of Zn stabilizes the tertiary structure of Zn finger, which is relevant to the DNA replication and transcription. Zinc is also known to activate more than 300 kinds of enzymes and proteins. Another important application of the metallomics study is evaluation of the toxicity and distribution of toxic elements, such as Hg, As, Cd, and Pb, which would present in the creatures at ultratrace levels (< ~μg g−1). Metallomics is a scientific research field in symbiosis with genomics and proteomics, because biosyntheses and biological functions of nucleic acids (DNA and RNA) and proteins cannot be carried out without the aid of various metal ions and metalloenzymes. In the metallomics study, to take a full advantage of the metal ions or meta-binding biomolecules, analytical technique with sensitive, fast, and user-friendly mass spectrometry techniques, including an ICP-mass spectrometry (ICP-MS) are highly desired. In this session, we would like to discuss the current situation of the metallomics studies using the mass spectrometry, and also to share the potential clue to promote the metallomics studies.
■Keywords
Metallomics, Inorganic mass spectrometry, Speciation, Stable isotope, Imaging
■Title
Real-time mass spectrometry for qualitative/quantitative analysis of volatile compounds
■Organizer
Kanako Sekimoto (Yokohama City Univ.) / Motoshi Sakakura (AMR Inc.)
■Keynote
Akira Tani (Univ. Shizuoka)
■Scope
Interest in real-time mass spectrometry is increasing in a wide variety of fields dealing with volatile compounds, such as atmospheric environmental chemistry and food and flavor sciences. Direct analysis in real time mass spectrometry (DART-MS) and proton-transfer-reaction mass spectrometry (PTR-MS) have become well-established analytical techniques for real-time measurements of volatile compounds in ambient air. However, it is still difficult to comprehensively and accurately identify and quantify a large number of compounds whose concentrations can change in seconds. In this session, we call for the presentations regarding state-of-the-art real-time mass spectrometry techniques that enable accurate and comprehensive quantitation, identification, and isomer discrimination of volatile compounds. The sharing of valuable application experiences and new ideas is also welcome.
■Keywords
Volatile compound, Real-time analysis, Quantification, Qualification, Identification
■Title
Mass spectrometry for on-site environmental analysis
■Organizer
Yuko Omori (Univ. Tsukuba) / Teruyuki Maruoka (Univ. Tsukuba)
■Keynote
Hiroshi Tanimoto (National Inst. Environm. Studies)
■Scope
Samples must be transported from sampling sites when laboratory-installed mass spectrometers are used, but field-portable mass spectrometers enable us to analyze various target samples “on-site”. With time from sampling, the physical parameters of a material, such as temperature, pressure, or redox state, may change, which may alter its chemical states, such as molecular compositions and chemical species. Therefore, analytical results obtained in laboratories may not always reflect the chemical states of a material at its sampling site. On-site analysis is the only means to avoid such discrepancies, especially when the target material includes a liquid or vapor because their chemical states can easily alter after sampling. In this session, we will discuss on-site mass spectrometry techniques to advance research in the earth, space, and environmental sciences.
■Keywords
On site mass spectrometry, Environmental sciences, Process gas analysis, Space exploration, Oceanography, Volcanology
■Title
New dimension of protein research driven by mass spectrometry
■Organizer
Tadayuki Ogawa (Univ.Tokyo) / Tomoya Kinumi (AIST)
■Scope
A variety of protein structures provide their specific function, which forms the basis of biological systems. Therefore, accurate and precise analyses of protein structure and function will deepen our knowledge in the fundamental behavior of the molecules in biological systems and pathogenesis. Mass spectrometry (MS) has been a strong tool for protein analyses of primary structure and post-translational modifications. Recently, high-resolution MS and ion mobility MS enabled further protein analyses to investigate supramolecular complex, protein conformation, and its application for the medical use. From this perspective, this session focuses on the MS-driven protein analyses in various fields, from the basic research to the medical application, and discuss about the seamless fusion of multiple analyses.
■Keywords
Protein, Post-translational modification, Protein complex, Native MS, Ion mobility MS
■Title
From open data to data science
■Organizer
Shin Kawano (Database Center Life Sci.) / Atsushi Fukushima (RIKEN)
■Scope
In recent years, registration of experimental data in the public databases is indispensable for publication because of worldwide trends of open science. In the field of image analysis, machine learning methods using a large amount of public shared data are achieving results. Data sharing and data analysis using shared data are expect to be more popular even in the field using mass spectrometers. In this session, we will introduce the current status on the development of databases in proteomics and metabolomics, and the latest trends on the tools and machine learning methods using shared data.
■Keywords
Open science, Data science, Big data, Database, Machine learning
■Title
Ion mobility spectrometry and ion-molecule reactions
■Organizer
Shinji Nonose (Yokohama City Univ.) / Fuminori Misaizu (Tohoku Univ.)
■Keynote
Jun-ya Kohno (Gakushuin Univ.)
Ion mobility spectrometry (IMS) and ion-molecule reactions provide a broad feature not only for practical applications but also in fundamental studies of gas-phase ion chemistry. In particular, IMS is now an important tool in structural biology for mass analysis of biomolecules such as peptides, sugars, proteins, and protein complexes. This session will focus on practical and fundamental aspects of IMS and ion-molecule reactions.
■Keywords
Principle of ion mobility analysis, Elementary process on ion-molecule reaction, Kinetics of ionization
■Title
Novel developments of sample injection, ionization, and ion separations
■Organizer
Hajime Mizuno (Univ. Shizuoka) / Daiki Asakawa (AIST)
■Scope
Mass spectrometry is widely used in various fields including life sciences, food and environmental sciences, material developments and so on. With such analytical research aims, the devices equipped new ionization or ion dissociation techniques has been developed and fundamental researches related to the ionization and/or ion dissociation processes has been performed. In this session, we call for a wide range of presentations on ionization, ion transportation, dissociation, and related hardware and technologies. We would like to share the latest knowledge and discuss next generation mass spectrometry technology.
■Keywords
New device, Hardware development, Sample injection, Ionization, Ion dissociation, Ion optics
■Title
Mass spectrometry for the manufacturing products
■Organizer
Masaki Sato (Kyocera Corp.) / Kei Ishitsuka (AGC Inc.)
■Scope
Due to the raising of emerging countries, it is long since the fall of competitiveness of manufacturing in Japan. Under such circumstances, the mission of those involved in analysis will be to promptly deliver better evaluation technology and more reliable analysis data to the site of manufacturing and R&D, contributing to new product development and quality control. For the most effective process, it is necessary to promote the development of evaluation technology for manufacturing, together with domestic supply chains (to setup from materials), contract analysis manufacturers, equipment manufacturers and academia. Particularly in mass spectrometry, it is expected that it will be one of the indispensable technologies for material analysis from the viewpoint of detection sensitivity and high versatility. In this session, we will present the topics from a wide range of fields such as preparation (separation / purification), ionization, high resolution MS, imaging and data analysis, etc. targeted to industrial product related materials like polymers, additives and mixtures. We would like to share solutions and issues, and make the session a place to promote "co-creation" of material analysis technology, discussing the idea of future analytical methods each position.
■Keywords
Industrials materials, Evaluation technology, Acceptance test, Quality evaluation, Supply chain, Co-creation
■Title
Captivating topics from drug development: Analysis of new modality compounds and biomarkers by mass spectrometry
■Organizer
Yoshihisa Sano (Sunplanet Co., Ltd.) / Nana Kawasaki (Yokohama City Univ.)
■Scope
Development of new drugs is getting harder and the targets of the drug candidates are moving on to so-called new modalities, e.g. high molecules including antibodies, natural products, nucleic acids, peptides, and sort of hybrid molecules from conventional low molecule compounds. Alongside of this transformation, LC-MS/MS as a representative of mass spectrometry has been drastically developed and improved to detect these new molecules, even there have been certain traditional analysis methods such as ligand binding assays. Now a large number of results have been reported with satisfactory sensitivity and reproducibility utilizing LC-MS/MS. In this session, we would like to share these implementation examples from pharmaceutical industries, CROs, and academia, and discuss some future perspectives on this crucial topic.
■Keywords
Drug development, New modality, Antibody drugs, Quantification, Nucleic acid, Quantitative analysis
■Title
Imaging mass spectrometry - Current issues and future prospects -
■Organizer
Takaya Satoh (JEOL Ltd.) / Yasuo Kuroki (Thermo Fisher Scientific K.K.)
■Scope
Recently, the fundamental technology on an imaging mass spectrometry has reached a certain level, and the application field in biological samples and industrial materials, etc. is widely broadening. Because, both basic technologies and applications are closely connected with each other, it is necessary to develop new basic technologies or improve existing technology to solve the current issues in application fields. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), secondary ion mass spectrometry (SIMS), desorption electrospray ionization mass spectrometry (DESI-MS), laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), etc. are available for imaging mass spectrometry. Each of the imaging mass spectrometry method is combination of various kinds of technologies such as pretreatment, ionization, mass separation. In this session, we will focus on the present situation and issues on imaging mass spectrometry used for inorganic and organic analysis. We also welcome the presentation on new technology development, exchange information on the future of imaging mass spectrometry and deepen the discussion.
■Keywords
Imaging mass spectrometry, Pretreatment, Instrumentation, Data analysis
■Title
Mass spectrometry of lipids
■Organizer
Mitsutoshi Setou (Hamamatsu University School of Medicine) / Kazutaka Ikeda (RIKEN)
■Keynote
Akio Hayashi (Ono Pharmaceutical Co., Ltd.)
■Scope
Today, our government pushes forward the LIPID research with AMED and JSPS big grants. Since mass spec is inevitable for recent lipid analysis, active research and development, information exchange is ongoing with those groups, including seminars and practice courses. In this session, leaders of this community will present their up to date knowledge and skills, including daily tricks, pitfalls, and new techniques for imaging and or non-target analysis.
■Keywords
Lipid, Quantification, Target analysis, Non-target analysis, Imaging
■Title
Session for young researchers: Perspective for fundamental study
■Organizer
Ken-ichi Bajo (Hokkaido University) / Yoshiki Makino (University of Tokyo)
■Keynote
Takaaki Itai (University of Tokyo)
■Scope
This session is dedicated to young researchers, who would like to introduce their fundamental and/or novel researches utilizing mass spectrometry in various fields. We hope that each research would be developed through interdisciplinary discussion in this session. We also welcome the presentation of graduate students. We also would like to discuss the future perspective of mass spectrometry from a viewpoint of young researchers.
■Keywords
Young researchers, Future perspective
■Title
Application of imaging mass spectrometry in drug development
- Standardization of technology towards application studies -
■Organizer
Shuichi Shimma (Osaka University) / Yukari Tanaka (Shionogi Co., Ltd.)
■Scope
Imaging mass spectrometry (IMS) has a potential analytical technique in drug development especially, pharmacokinetic/pharmacodynamic (PK/PD) and toxicological studies. Recently, CROs (domestic/global) have also introduced IMS services, therefore outsourcing analysis is available. We consider the number of potential IMS users will be increased in the future. This situation suggests that standardization of sample preparation, quantitation and other techniques related with IMS is one of the important issues. In this session, we offer the valuable opportunities to discuss fundamental to advanced techniques and applications of IMS focused on pharmaceutical analysis.
■Keywords
Imaging mass spectrometry, Drug development, Standardization, Sample preparation
■Title
Creating innovation by developing better understanding between drug discovery and mass spectrometry
■Organizer
Shuichi Matsuda (Ono Pharmaceutical Co., Ltd.) / Masato Iwaya (Japan Tobacco Inc.)
■Keynote
Takatoshi Kuno (Shonan Health Innovation Park)
■Scope
Mass Spectrometry is essential technology for current drug discovery research. However, it has been being more difficult to apply them for the field of ‘REAL’ drug discovery due to their technology advanced, specified and high expertise. We believe that technology sharing and co-development of instruments which can overcome challenges for various research fields (HTS, pharmacokinetics, safety, efficacy, etc.) among several pharmaceutical companies will be needed in the future in order to transform recent advances in mass spectrometry into our innovation. The main purpose of this workshop is to develop better understanding between drug discovery and mass spectrometry as a first step. In this workshop researchers from the pharmaceutical industry will offer a presentation not only about their analytical methods, but also about the challenges they are facing in their drug discovery field. We hope that this workshop can give participants the opportunity to envision what we can do with mass spec for drug discovery.
■Keywords
Drug discovery,Creating innovation,Accumulation of technologies,Better understanding between drug discovery and mass spectrometry

Workshop

■Title
Fundamental and practical aspects of LC/MS; Characteristics of ion detection systems
■Organizers
Masayuki Kubota (Thermo Fisher Scientific) / Yoshihiko Takinami (Bruker Japan K. K.)
■Scope
MSSJ Corporate Program Working Group (MSSJ CPWG) is organizing a consortium of instrument manufacturers. One of the objectives of this effort is to bridge the society and a wide range of MS users and encourage people to attend the annual conferences and join the society. To pursue this end, CPWG plans to hold serial workshops that would be attended by many ordinary MS users to share common problems and exchange information. In the past three workshops, we focused on “matrix effect”, “mass separation mechanism and MS/MS analysis” and “ion transfer systems”. In this year's workshop, we focus on ion detection systems. There are some typical ion detection systems and they combined with optimum ion separation techniques each other. These combinations are characteristics of instrument, and it is why it selects a device according to the application. On this session, each presenter will explain about the typical ion detection systems with their characteristics. Also, we are planning a panel discussion for a deeper understanding.
■Keywords
LC-MS, Ion detection system, Pulse counting, Transient signal
■Title
“MS café”: Work/Life Balance with Your Determination and Choice
■Organizers
Gender Equality Committee
Tadayuki Ogawa (Univ. Tokyo) / Seiko Oka (Hokkaido Univ.)
■Scope
In the dynamically changing world, we attempt to achieve the affluent and active society based on our enriched creativity and problem-solving abilities through inclusion and diversity. Gender equality committee of MSSJ desires the effective inclusion of diverse participants into our society, and constitutively commits to have the equal opportunity for them to participate in all kinds of social activities, enjoy benefits, realize their full potential and share responsibilities. From this perspective, we organize this “MS café” workshop at the annual conference on mass spectrometry in order to introduce and discuss about not only MS-related works but also information in our various lifestyles. (Snacks and drinks will be provided.)
■Keywords
m/z, W/L, work-life balance, Inclusion, Diversity, Gender Equality