Table of contents
Oral Sessions (Day1, Day2, Day3)
Poster Presentations
(Day1, Day2, Day3)
Poster Presentations
- Day 2, May 16(Thu.) Room P (Multi-purpose Hall)
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2P-22 PDF
Analysis of Impurities of Therapeutic Oligonucleotides via LC/TOF-MS
Oligonucleotides are chemically synthesized compounds and have recently attracted attention as a “new modality”. Due to the large molecular weight of oligonucleotides, TOF/MS is used for the analysis because of its wide mass range, but analysis of impurities is considered as a bottleneck for automation. We show that several split impurities are detected in degradated sample of 21mer using by LC/TOF-MS and Oligosearch software.