演題概要

ポスター発表

第1日　5月15日（水）　　P会場（多目的ホール）

1P-28　　PDF

W突然変異マウスのWhisker毛包における組織プロテオーム解析

(¹同志社大生命医・ ²滋賀県立総合病院研究所・ ³ブルカージャパン)
^o小杉茉由佳¹・ 木下和生²・ 韮澤崇³・ 梶田遼³・ 角田伸人¹・ 池川雅哉¹

The proto-oncogene c-kit mapped to the white-spotting (W) locus in mice encodes the receptor tyrosine kinase (KIT). The Signaling pathway of KIT and its ligand, stem cell factor (SCF) is important for migration, proliferation and differentiation of melanocytes. Homozygous W mutant mice have white coat color against black coat color in wild type. Here we established a novel strategy to study effects of KIT on morphogenesis of Whisker follicles of W mutant mice. In addition to histological analysis, we studied proteomic landscape using matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) with timsTOF Pro system.