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Day 3, June 12（Wed.） Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)
- 3P-17
Measurement of Digitalis-Derived Intoxicants in Blood Using LC-MS/MS
(1Japan Healthcare Univ., 2Hokkaido Univ.)
oRyo Uozumi1, Shigeki Jin2, Kotaro Matoba2
Digitalis is similar in appearance to an edible wildflower, and poisoning by accidental ingestion has been reported. Digitalis contains toxins (inotropic glycoside) called digitalis toxin, which can cause poisoning symptoms. The detection of digitalis toxins is necessary to confirm the diagnosis of digitalis poisoning. In this study, we report on the measurement of digitalis toxins in the serum of a patient suspected of digitalis toxicity using LC-MS/MS. Sample preparation was performed by solid-phase extraction, and reversed-phase columns were used for LC-MS/MS. Detection was by the selected reaction monitoring (SRM) method in positive ion mode. The result of analysis showed high levels of digitoxin in the patient's serum, supporting the diagnosis of poisoning.