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Day 3, June 12（Wed.） 14:15-14:33 Room D (Conference Room 202)
- 3D-O2-1415
Hybrid Imaging of Biological Tissues: Toward the Atlas of Molecules, Elements, and Metals in Brain
(1Dokkyo Med. Univ., 2Univ. Tokyo, 3Tokyo Univ. Phar., 4QST)
oTadayuki Ogawa1, Eisei Tanaka2, Hiroki Nawa2, Tomonari Umemura3, Shino Takeda4, Takafumi Hirata2
In our body, various molecules constitute tissues and organs, and work efficiently to fulfill their physiological function in a coordinated and dynamic manner. When the molecular coordination breaks down for some reason, its pathological modulation appears as a disease. Therefore, it is important to obtain as much information as possible about the quality and localization of all molecules and atoms on the tissue and to analyze them precisely in an integrated manner. In this presentation, we introduce the integrated analyses of the same brain tissue by applying theoretically different imaging analyses, combining the conventional histological analyses with MALDI (matrix-assisted laser desorption/ionization)-IMS (imaging mass spectrometry), SALDI (surface-assisted laser desorption/ionization)-IMS, Nano-PALDI (Particle Assisted Laser Desorption/Ionization)-IMS, LA (laser ablation)-ICP-MS, PIXE (particle induced X-ray emission), and HE-SR-XRF (high-energy X-ray fluorescence spectrometry) imaging. Our studies show the integrated molecular imaging analyses is a promising approach that can deepen our knowledge about the localization of biological molecules in the central nervous system and disease brains during pathogenesis.