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Fundamental Sessions
Day 3, June 12（Wed.） 9:15-9:33 Room D (Conference Room 202)
- 3D-O1-0915
Mass Spectrometry Imaging of Dilated Cardiomyopathy Tissues by Tapping-mode Scanning Probe Electrospray Ionization
(1Osaka Univ., 2Osaka Univ., 3Osaka Univ., 4Osaka Univ.)
oYoichi Otsuka1,2, Shuichi Shimma3, Hidetaka Kioka4, Tomohito Ohtani4, Yasushi Sakata4
Mass spectrometry imaging of cardiac tissue donated by a patient with human dilated cardiomyopathy was performed using t-SPESI measurement system. Lipids localized in the fibrotic region and widely distributed in the myocardium were visualized. We found that the ion signal intensities of lipids presumed to be acylcarnitines were greatly decreased in cardiomyocytes near the fibrotic region.