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Poster Presentations
Day 2, June 11（Tue.） Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)
- 2P-27
Metabolomic Analysis of Liver-specific 67-kDa Laminin Receptor Knockout Mice with Liver Fibrosis
(Kyushu Univ.)
oTomomi Ichinose, Takuro Yoneyama, Natsuko Takeshita, Risa Nishikido, Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana
The 67-kDa laminin receptor (67LR) functions as a receptor for epigallocatechin-3-O-gallate (EGCG), a type of green tea catechin. However, the biological roles of 67LR are unclear. Liver-specific 67LR knockout (67LR-KO) mice showed liver fibrosis. In this study, we investigated the relationship between metabolic states and the progression of liver fibrosis in 67LR-KO mice by metabolomic analysis. Hydrophilic metabolites extracted from livers were analyzed using LC-MS-based targeted metabolomics. The LC-MS datasets were subjected to multivariate statistical analyses. The liver metabolome data from 67LR-KO and control mice were subjected to principal component analysis (PCA), which showed different variance between the two groups on the score plots, and also genotypic differences were observed in orthogonal partial least squares discriminant analysis (OPLS-DA). Metabolites reported to be decreased in mouse models of liver fibrosis tended to be decreased in 67LR-KO mice. The levels of some metabolites from various pathways were altered by 67LR-KO.
The presence of multiple metabolites in the liver of 67LR-KO mice, depending on their fibrotic status, these metabolic changes may be associated with liver fibrosis in 67LR-KO.