The 72nd Annual Conference on Mass Spectrometry, Japan
Date:
Mon, Jun 10, - Wed, Jun 12, 2024
Venue:
Tsukuba International Congress Center (Takezono, Tsukuba City, Ibaraki Prefecture 305-0032, Japan)
  •  
  •  
  •  
  •  

Abstract

Poster Presentations

Day 2, June 11(Tue.)  Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)

2P-24
PDF

Structural Confirmation of Polyoxazoline-Conjugated Albumin as New Artificial Blood

(1Shimadzu, 2Chuo Univ.)
oTakashi Nishikaze1, Yuzo Yamazaki1, Teruyuki Komatsu2

The medical demand for animals, especially those kept as pets, is increasing year by year, but the infrastructure for blood transfusion therapy remains inadequate. Recently, we (Komatsu Lab team, Chuo University) have developed a new artificial blood product (artificial plasma) for pets “polyoxazoline (POx) conjugated albumin.” This formulation is created by chemical modification of readily available porcine-derived albumin (PSA) with POx and can be safely administered to dogs and cats. In this study, we present an example of the structural confirmation of POx-PSA using a matrix-assisted laser desorption/ionization time of flight mass spectrometer (MALDI-TOF MS).