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Poster Presentations
Day 2, June 11（Tue.） Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)
- 2P-18
Visualization of Drug/Metabolites and Metabolism with DESI TQ and DESI Q-Tof Mass Spectrometers
(1Nihon Waters, 2Waters)
oEtsuko Suzuki1, Thanai Paxton1, Emmanuelle Claude2, Naysha Munjoma2, Joanne Ballantyne2
Typically, DMPK studies are performed using LC/MS with ESI of biofluids and tissues that have been homogenized and therefore the molecular localization is lost. DESI mass spectrometry imaging (MSI) allows the determination of small molecule distributions directly from tissue, such as pharmaceutical compounds and their metabolites as well as endogenous molecules.
Here a DESI source mounted on either a high-resolution Q-Tof or a TQ MS were used in a multi-step workflow allowing the localization of Gefitinib and its metabolites in liver, with timed collection, to monitor DMPK and the metabolism over time, directly from tissue section.