Program

Timetable

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Plenary Lectures

[Program]

■Plenary Lecture 1

COVID-19 vaccine and immune response
Michinori Kohara (Tokyo Metropolitan Institute of Medical Science)

■Plenary Lecture 2

Applying Ambient Mass Spectrometry for Characterization and Imaging Neurotransmitters, Metabolites and Drugs on Whole Human Body Skin
Jentaie Shiea (National Sun Yat-Sen University)

Society Featured Lecture

[Program]

■Society Featured Lecture

Research and Development of Scanning Probe Electrospray Ionization
Yoichi Otsuka (Osaka Univ.)

Oral Sessions

■Day 1 Wednesday, May 19 [Program]
■Day 2 Thursday, May 20 [Program]
■Day 3 Friday, May 21 [Program]

Session Overview

■Session No

1A-O1

■Title

Diversity of natural products and mass spectrometry

■Organizer

Hiroyuki Koshino (RIKEN) / Ryuichi Sawa (IMC)

■Keynote

Hedeaki Oikawa (Hokkaido Univ.)

■Scope

Natural product is a metabolite produced by animal, plant, and microorganism. It includes aroma, pigment, taste components as familiar compounds, and also a lead compound in drug discovery, natural toxin, hormone, and pheromone as a biological active compound with strong and selective activities. It is categorized biogenetically as polyketides, terpenoids, amino acids, peptides, alkaloids, flavonoids, saccharides, lipids, and so on with diversity. Recently, several biosynthetic mechanisms have been revealed and applied to produce natural products including novel compounds by a transgenic microorganism. We would like to discuss on mass spectrometry which is widely used as an essential analytical tool for several analyses on topics of recent natural product chemistry, and on the future.

■Keywords

biosynthesis, structure elucidation, fragmentation, imaging, dereplication

■Session No

1B-O2

■Title

Integrated Omics for Hypothesis Generation

■Organizer

Yoshiya Oda (Univ. Tokyo) / Taka-Aki Sato (Shimadzu Co. / Univ. Tsukuba, R&D Center for Precision Medicine)

■Keynote

Taka-Aki Sato (Shimadzu Co. / Univ. of Tsukuba, R&D Center for Precision Medicine)

■Scope

With the evolution of mass spectrometry, next-generation sequencers, and information science, genomics, proteomics, and metabolomics have become widespread, and various types of omics are now being performed on cell extracts and clinical specimens. However, omics is a tools and not the goal. The goal is to elucidate disease mechanisms and medical applications. In other words, the first step toward achieving the goal is to find the hidden door through omics and create a hypothesis. However, there are many cases in which one omics alone does not provide enough information to construct a hypothesis. Also, in the case of human subjects, for example, it may be difficult to infer novel mechanisms using only plasma samples. Therefore, in order to combine several methods, we would like to discuss whether it is possible to construct a hypothesis by performing multiple omics on one type of sample, or by performing omics on samples obtained from different multiple sampling sources, such as blood and urine.

■Keywords

Multi-omics, Systemic-omics, Integrated-omics, Hypothesis, Mechanism

■Session No

1C-O3

■Title

State-of-the-art mass spectrometry techniques for material analysis

■Organizer

Takaya Satoh (JEOL Ltd.) / Shogo Yamane (AIST)

■Scope

Recent years, the development of functional materials that require quality control at the molecular level is progressing in industrial fields. Mass spectrometry is an important tool for obtaining chemical information in various phases such as development, mass production, and defective/deteriorated analysis of the products. While mass spectrometry provide various information, the analysis software which can be converted the results into knowledge will be very important in the actual field. In this session, we will discuss the current trend of mass spectrometry techniques (pretreatment, ionization, mass spectrometry) and software that will enhace the analysis of an industrial materials.

■Keywords

Industrial Materials, Pretreatment (Separation/Purification), Ionization, Ion Mobility, High Resolution MS, Imaging, Data Analysis

■Session No

1D-O4

■Title

Novel development of fundamental technique and application of the ion beam

■Organizer

Hiroyuki Matsuzaki (Univ. Tokyo) / Hirochika Sumino (Univ. Tokyo)

■Keynote

Hidetsugu Tsuchida (Kyoto Univ.)

■Scope

The ion beam generated by accelerators has excellent characteristics: pure ion component, uniform direction and energy, controllable current, etc. Using these characteristics, various analytical techniques for trace elements and extremely rare isotopes have been developed, and applied for dating, environmental dynamics analysis, and materials evaluation. Accelerator Mass Spectrometry is, for example, one of these techniques and well known to be used radiocarbon dating. However recent development tends to make the accelerator smaller as several 100s kV. On the other hand, innovative mass spectrometry system has improved its abundance sensitivity greatly. This session will survey update technical development of generation, control, and detection of ion beam both with and without accelerator. Also surveying recent results of application including environmental dynamics analysis, materials modification by ion beam doping, and studies for fundamental mechanisms of therapy, we will prospect the new phase of the research area of “mass spectrometry and ion beam sciences”.

■Keywords

Ion accelerators, Accelerator Mass Spectrometry, Advanced mass spectrometry, ion beam, Environmental dynamics analysis, Fundamental therapy mechanism

■Session No

1E-O5, 3F-O16

■Title

Session for young researchers: Perspective for fundamental study

■Organizer

Shu Taira (Fukushima Univ.) / Issey Osaka (Toyama Pref. Univ.)

■Scope

This session is dedicated to have a diverse group of "young researchers" who are interested in self-improvement, PR, career building, and creating memories through research presentations. Mass spectrometry has become a technique used in various scientific fields. Thus, we desire you although central data is not MS. We hope you will find a colleague who will carry the conference with you in the future through discussion. Presentations by graduate students are more than welcome. Those who aim to become Principal Investigators (P.I.) in the future are also desirable. We would like to share an enthusiasm and information on how you have made efforts and innovations to continue research activities under Corona Damages.

■Keywords

Young researchers, Future perspective

■Session No

2A-O6

■Title

Challenges and prospects for the standardization of mass spectrometry-based omics science

■Organizer

Daisuke Miura (AIST) / Hiroshi Tsugawa (RIKEN)

■Scope

In recent years, improvements in data analysis technologies, such as AI and deep learning, have raised attention to data mining through big data analysis using these technologies. Although various metabolite biomarkers have been explored in metabolomics and lipidomics through comprehensive analysis of biological samples, they have not yet been developed for practical use. This is due to the fact that various facilities have constructed various analysis methods, and the differences between them may have a significant impact on the results. In addition, even when the same analytical method is used, there is a large difference in the intra-day, inter-day, and inter-institutional variability, and these problems hinder the accumulation of big data using metabolomics and lipidomics. In this session, we will review the challenges and prospects for standardization of mass spectrometry-based omics science, and discuss the future efforts of industry, government, and academia as a whole.

■Keywords

Metabolomics, lipidomics, automation of measurement, annotation, database

■Session No

2B-O7

■Title

Current status and prospects for mass spectrometry of biological products

■Organizer

Kazutaka Shimbo (Ajinomoto Co., Inc.) / Nana Kawasaki (Yokohama City Univ.)

■Keynote

Hiroyuki Kaji (AIST)

■Scope

Manufacturing using mammalian cells, plants, microorganisms, etc. is important not only for application to complex biological substances that are not easy to produce chemically synthesized such as proteins, but also for the realization of a sustainable society. In particular, the new modalities such as vaccines, biopharmaceuticals, nucleic acid drugs, regenerative medicine, etc. has attracted a great attention, and various mass spectrometry methods are being developed rapidly toward those practical applications. In addition, the detection of recombinant proteins such as growth hormone and erythropoietin are also one of the critical issues of doping in sports. In this session, we would like to discuss the current situation and future prospect of mass spectrometry methods for various biological products and blood doping.

■Keywords

vaccines, nucleic acid drugs, regenerative medicine, biopharmaceuticals, blood doping

■Session No

2C-O8

■Title

Mass spectrometry for sample return missions

■Organizer

Ken-ichi Bajo (Hokkaido Univ.) / Teruyuki Maruoka (Univ. Tsukuba)

■Keynote

Hiroshi Naraoka (Kyushu Univ.)

■Scope

A sample return mission is a spacecraft mission with the goal of collecting and returning samples from an extraterrestrial object to the Earth. The first returned sample was obtained from the moon by Apollo 11 mission on 1969. According to the Apollo mission, scientists revealed a formation history of the moon by radiometric dating and isotope analyses with a lot of types of mass spectrometers that were developed for the Apollo mission. After the Apollo mission, mass spectrometry techniques have been progressively improved especially for the limited size of samples. This improvement enables us to restart the sample return missions using a small asteroid explorer, such as Hayabusa, Hayabusa 2, and OSIRIS-Rex, which launched during the last two decades. Here we introduce and discuss the novel mass spectrometry and latest researches in planetary sciences.

■Keywords

Hayabusa 2, OSIRIS-REx, sample return mission, planetary science, origin and evolution of the solar system

■Session No

2E-O9

■Title

The Path of Gas-phase Ion Chemistry: Understanding Ionization and Excitation Processes and Gas-phase Ion Reactions

■Organizer

Takae Takeuchi (Nara Women's Univ.) / Satoshi Ninomiya (Univ. Yamanashi)

■Keynote

Kenzo Hiraoka (Univ. Yamanashi)

■Scope

Our keynote speaker has been at the vanguard of this field for the past several decades and always strives to make novel discoveries such as the ones in the paper that will be presented to us. This session will give us an opportunity to improve our theoretical and experimental understanding of ionization and excitation processes and gas-phase ion reactions.

■Keywords

Ionization Method, Ionization/Excitation Process, Gas-phase Ion Chemistry, Reaction Mechanism, Theoretical Chemistry

■Session No

2F-O10

■Title

How can we understand mass spectral data accurately?

■Organizer

Kanako Sekimoto (Yokohama City Univ.) / Yayoi Hongo (OIST)

■Keynote

Takeshi Ara (Kyoto Univ.)

■Scope

Modern mass spectrometry has progressed the development of softwares with various algorithms to analyze massive mass spectral data. Key factors for those analysis are “m/z” and “ion intensities”. Thus, accurate understanding of each mass spectrum is required. In this session, we will discuss how raw mass spectral data is interpreted accurately (in ion characterizations), based on really-experienced examples.

■Keywords

Mass spectrum, Ion intensity, Quantitative analysis, Qualitative analysis

■Session No

3A-O11

■Title

Biomarker searching for novel clinical biomarkers based on mass spectrometry technology

■Organizer

Masamitsu Maekawa (Tohoku Univ.) / Ryuichi Mashima (National Center for Child Health and Development)

■Keynote

Ryuichi Mashima (National Center for Child Health and Development)

■Scope

Mass spectrometry technology centered on omics analysis has revealed the existence of a wide variety of molecules in human body. There are many molecules in which the structures are still unknown, however they are detected. Biomarkers, those are widely used in medical treatments, especially in clinical diagnosis. In recent years, many biomarkers have been identified and are being applied medically with the progress of structural analysis technology that makes full use of mass spectrometry and the improvement of comprehensiveness and sensitivity of mass spectrometry. Therefore, in this session, we call for the presentations on mass spectrometry-driven biomarker research, such as the discovery and identification of new biomarkers that make full use of mass spectrometry and diagnostic methods based on their quantification, and will broadly discuss their usefulness and issues.

■Keywords

Biomarkers, Identification, Discovery, Quantification, Structural determination

■Session No

3B-O12

■Title

Frontiers in Proteomics and Protein Research

■Organizer

Takeshi Kawamura (Univ. Tokyo) / Yoshio Kodera (Kitasato Univ.)

■Scope

Proteomics has become an essential filed in life sciences. Mass spectrometry-based proteomics basically enable protein identification (and quantification). Equipments, approaches, and data analyses in this field are continuously improving. Their application covers from diseases like cancer to emerging infectious diseases like COVID-19. Post-translational modifications and proteoforms are still challenging subjects. In this session, we will share state-of-the-art approaches and outcomes, discuss, and prospect the future directions in mass spectrometry based protein research and proteomics.

■Keywords

Identification, Quantification, Proteoforms, Data analysis, DIA, PTM, Diseases and infections, Single-cell analysis

■Session No

3C-O13

■Title

Frontiers in Metallomics

■Organizer

Takafumi Hirata (Univ. Tokyo) / Yasumitsu Ogra (Chiba Univ.) / Akitoshi Okino (Tokyo Tech.)

■Keynote

Akitoshi Okino (Tokyo Tech.)

■Scope

A scientific term “Metallomics” has been coined by Professor Hiroki Haraguchi (Professor Emeritus, Nagoya University) in 2002, and this term means a research field as an integrated science aimed at systematization of metal functions and physiological functions in living organisms. Nowadays, it is clarified that a trace amount of metal plays important roles involving in several physiological and pathological functions such as gene expression, cell signaling, and metabolism. These significant effects in a body and a cell depend on the content and chemical species of metal. Thus, Metallomics are closely and functionally related to genomics, proteomics, and metabolomics, and the integrated knowledge of these multi-omics study is expected to reveal the pathogenic progressions of several common diseases, such as dementia, diabetes, Alzheimer and cancer. Due to the unique physico-chemical properties, the development of new metal containing therapeutic agents is also expected. Currently, Metallomics is towards single cell analyses for metal imaging and speciation, then, imaging analysis of nanoparticles. These trends lead us to develop new analytical techniques based on mass spectrometry. In this session, we intend to exchange our knowledges on the current status and issues of Metallomics, and discuss the latest trends in mass spectrometry.

■Keywords

Metallomics, Inorganic Mass Spectrometry, Speciation Analysis, Single Cell Analysis, Nanoparticles

■Session No

3D-O14

■Title

Mass spectrometry technology to reveal the molecular structure

■Organizer

Kazumi Saikusa (AIST) / Daiki Asakawa (AIST)

■Scope

Mass spectrometry (MS) provides a variety of structural information from small molecules to biosupramolecular complexes. In addition, ion mobility spectrometry (IMS) allows the separation of ions according to their collision cross section. Consequently, IMS coupled with MS (IM-MS) has been recently used for structural analysis of variety of molecules specially for reaction mechanism of small molecules, separation of isomers, and higher-order structure of biomolecules. In this session, we will discuss a wide range of research for elucidating molecular structures, such as instrumental improvements including ionization, various analytical methods, computational science methods that support them, and their applications.

■Keywords

Biomolecule, Protein, Computational science, Ion mobility, Fragmentation, Ion molecular reaction

■Session No

3E-O15

■Title

Environmental science field by mass spectrometry

■Organizer

Hiroto Kawashima (Akita Prefectural Univ.) / Sachi Taniyasu (AIST)

■Keynote

Shigeki Masunaga (Yokohama National Univ.)

■Scope

Mass spectrometry has become an indispensable technology and a powerful tool in the field of environmental science. For example, in the dioxin problem of the 1990s, total isomer analysis made it possible to identify the source of the dioxin. On the other hand, the stable isotope ratio mass spectrometer has been used for simple and accurate isotope analysis of various compounds by combined with gas chromatography and elemental analysis etc., and its applications are now being actively studied not only in earth science but also in forensics science, sports science, and environmental fields. In this session, we would like to invite the latest presentations in the environmental field using mass spectrometry and stable isotope analysis, as well as technical reports not limited to the environmental field, and discuss these new technologies and their applications.

■Keywords

Microanalysis, Multi-component simultaneous analysis, Non-target analysis, Target analysis, Stable isotope analysis, Air, water and soil environment, POPS

Poster Presentations

■Day 3 Friday, May 21 [Program]

Workshops

■Day 2 Thursday, May 20 [Program]
■Day 3 Friday, May 21 [Program]

Workshop Overview

■Workshop No

2D-W1

■Title

Issues and solutions in quantitative analysis using LC / MS

■Organizers

Masayuki Kubota (Nihon Waters) / Takeshi Serino (Agilent)

■Workshop No

3B-W2

■Title

"MS cafe": Work Life & Passion during and after COVID-19