Abstract

Table of contents
Plenary Lectures
Award Lectures
Oral Sessions Day1, Day2, Day3
Poster Presentations Day1, Day2, Day3
Workshop
Luncheon Seminars Day1, Day2, Day3
Timetable

Poster Presentations

Day 3, May 19（Fri.）　　Room P (Multi-purpose Hall)

3P-18　　PDF

Imaging Mass Spectrometry for the study of cardiovascular pathology

(1Bruker Daltonics, 2Doshisha Univ., 3Georges Pompidou European Hospital, 4NCVC)
oTakashi Nirasawa1, Hiroko Namba2, Megumi Terada2, Toshiji Kudo1, Tomohiro Miyasaka2, Nobuto Kakuda2, Bruneval Patrick3, Hatsue Ueda4, Masaya Ikegawa2

Here we have developed a novel protocol for imaging mass spectrometry of human cardiovascular tissues. By using formalin fixed paraffin embedded biopsied samples, we have succeeded in visualization of peptides and proteins of the tissues with on tissue trypsinization. Comprehensive visualization of abnormal deposition of various peptide species was enabled with multivariate analysis. Furthermore, it is promising that this technique can identify unknown factor(s) regulating pathogenesis of the disease yet to be defined. Through these advancements, interinstitutional comparison must be the next step as well as antibody based validation for each biomarker candidate.