3C-O2-1505 PDF
Detection of Chirality in Mass Spectrometry on the Basis of Enantioselective Ligand Exchange of Organometallic ion
Enantioselective ligand exchange of chiral organometallic ion were examined using mass spectrometry coupling with the enantiomer labeled method. Three component complex ion, which consists of metal, chiral tetradentate ligand, and anion, was detected as base peak in electrospray ionization mass spectrometry. When amino acid was used as second ligand, the enantioselectivity was observed. The chiral discrimination does not reflect stability of the complex ion in the gas phase. Using equimolar mixture of enantiomers of deuterated complex (R,R) and unlabeled complex (S,S), enantiomeric excess of amino acid was determined in mass spectrometry only.