Abstract

Table of contents
Plenary Lectures
Award Lectures
Oral Sessions Day1, Day2, Day3
Poster Presentations Day1, Day2, Day3
Workshop
Luncheon Seminars Day1, Day2, Day3
Timetable

Poster Presentations

Day 2, May 18（Thu.）　　Room P (Multi-purpose Hall)

2P-18　　PDF

Tissue proteome profiling for the neuropathological study of murine experimental autoimmune encephalomyelitis by imaging mass spectrometry

(1Doshisha Univ., 2Bruker Daltonics, 3Kyoto Pref. Univ. Med., 4Kansai Med. Univ.)
oHiroki Yamashita1, Takashi Nirasawa2, Toshiji Kudo2, Katsutoshi Taguchi3, Masaki Tanaka3, Takayuki Kondo4, Nobuto Kakuda1, Masaya Ikegawa1

Murine experimental autoimmune encephalomyelitis (EAE) is the most common animal model for multiple sclerosis (MS). Here we applied matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) for the　neuropathological study of EAE. With the multivariate analysis including probabilistic latent semantic analysis (pLSA), we have confirmed that IMS is well suited for the visualization of spatial distributions of immune cells migrating into EAE brains as well as into spinal cords.