Abstract

Table of contents

Plenary Lectures: Award Lectures
Oral Sessions Day1, Day2, Day3: Poster Presentations Day1, Day2, Day3
Workshop: Luncheon Seminars Day1, Day2, Day3
Timetable

Oral Sessions

Day 2, May 18（Thu.）　10:10-10:30　Room C (101)

2C-O1-1010　　PDF

Strategies to analyze protein post translational modifications and isoforms in histones for epigenetic regulation

(¹Univ. Tokyo, ²Univ. Tokyo, ³Biosys Tech.)
^oTakeshi Kawamura^1,2, Kazuki Yamamoto¹, Yoko Chikaoka¹, Sujin Lee¹, Tetsuya Fukuda³, Toshiya Tanaka², Tatsuhiko Kodama²

Epigenetic modifications, which are the acquired genetic modifications, include DNA methylation and histone post-translational modifications (PTMs) such as methylation, acetylation, ubiquitination, and so on. Epigenetic changes are involved not only in life as proliferation, differentiation, and development and but also in diseases as cancer and lifestyle diseases. We are now working on epigenomics that target histones, including histone PTM analysis, searching for reader proteins that bind specific PTM, and drug screening for histone modifying enzymes. Here, we will report about strategies to analyze histone PTMs and variants.