1P-11 PDF
Proteomic Mass Imaging of Kidney from Type 2 Diabetes (T2D) Rat Model
Diabetic nephropathy is the most common cause of end stage renal failure. The development of an experimental animal model with diabetic nephropathy that closely mirrors human disease will significantly enhance our understanding of the nephropathy and accelerate our progress toward more effective treatments. A new inbred rat strain, Spontaneously Diabetic Torii (SDT) rats are excellent animal models to apply for this type of study. In this investigation, we demonstrate a comprehensive matrix-assisted laser desorption/ionization (MALDI) mass imaging mass spectrometry (IMS) approach to study the molecular distribution of proteins in diabetic kidney from SDT. Especially, we focus on the minimal changes of diabetic kidney at early stages of the disease progression.