演題概要

オーラルセッション

第3日 6月19日(金) 9:10~9:50 B会場(102)

メタボロミクスの基盤技術:技術開発の現状と今後の課題

(九大生医研)
o馬場健史

Lately, several analytical techniques for metabolomics have been developed and they have been applied in various fields, such as medicine, food, and the environment. However, metabolomics suffers from remaining problems, such as reproducibility and inefficiency (resulting from sample preparation, analytical instrument conditions, and data-processing methods), because of the poor understanding of how these three subject fields are linked. Additionally, metabolomics is mainly performed using three processes: sample preparation, instrumental analysis, and data mining, and the metabolomics technologies related to these processes are specific and very complicated. Many researchers, including our group, have been working on the development of various metabolomics technologies for more than 10 years. However, there remains room for improvement in the coverage of metabolites, quantitative performance, reproducibility, differences between experimental errors in different batches, etc. Additionally, it is necessary to develop a dynamic analysis system, because most metabolomics methods provide snapshots and cannot provide information about dynamic changes. Therefore, further improvements in analytical and data-mining techniques are needed to develop a more general and global approach to metabolomics. In this session, I will introduce current metabolomics technologies and I will also discuss important technology that is essential for next-generation metabolomics.