演題概要

ポスター発表

第1日 6月17日(水)  P会場

組換え糖転移酵素POMGnT1のO-結合型糖鎖解析

(都健康長寿医セ研)
o津元裕樹萬谷博遠藤玉夫三浦ゆり

Protein O-mannose β-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) catalyzes the addition of N-acetylglucosamine (GlcNAc) to O-linked mannose (Man) to give GlcNAcβ1-2Manα-Ser/Thr. To investigate the glycan structure and modification site of POMGnT1, we analyzed the tryptic peptides of POMGnT1 by LC-MALDI-TOF/TOF system and detected the glycopeptides containing mucin-type O-linked glycan.