1B-O2-1840 PDF
タンパク質複合体中の天然変性領域の振る舞い
Intrinsically disordered regions (IDRs) in proteins lack fixed 3D structure and recognize the target molecules by changing their molecular shape depending on the target. IDRs play various distinct functions especially in eukaryotes, but their structural characterization is not easy because X-ray crystallography cannot provide structural information on IDRs. In this paper, we discuss the gas-phase behavior of IDRs in protein complexes characterized by native mass spectrometry.