The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Workshops

Luncheon Seminars (Day1, Day2, Day3)

Poster Presentations

Day 3, May 13（Wed.）　　Poster (1008/09)

3P-27　　PDF

Investigation of urinary free-glycans as tumor marker candidates

(Res., Osaka International Cancer Institute)
oKen Hanzawa, Miki Tanaka-okamoto, Hiroko Murakami, Yasuhide Miyamoto

We focused on urinary free-glycans as potential tumor markers. Free-glycans were extracted from the urine of normal controls, pancreatic, gastric and lung cancer patients and labeled with 2-aminopyridine. The structural analysis of the glycans were performed by liquid chromatography and mass spectrometry. The amounts of the glycans were compared between healthy controls and cancer patients by selective reaction monitoring (SRM).
Several free-glycans, including N-glycan-fragments and extended glycans with lactose/N-acetyllactosamine- core were increased in some pancreatic and gastric cancer patients.