The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan

Program

Timetable

Timetable(PDF 77KB)
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Plenary Lectures

[Program]

Tomoyuki YATSUHASHI (Osaka City University)
Kimito FUNATSU (The University of Tokyo)

Oral Sessions

Day 1 Monday, May 11 [Program]
Day 2 Tuesday, May 12 [Program]
Day 3 Wednesday, May 13 [Program]

Session Overview

Session No.1
■Session No
1A-O1
■Title
Frontiers of protein and proteomics research
■Organizer
Jun ADACHI (Natl Inst Biomed Innov Health Nutr) / Yusuke KAWASHIMA (Kazusa DNA Res Inst)
■Invited
Fumiaki OHTAKE (Hoshi Univ)
■Scope
Mass spectrometry has become an indispensable analytical method for protein and proteomics research. In particular, large-scale analyses as well as targeted analyses of individual biomolecules to reveal the structure-function relationship have been explored by the state-of-the art mass spectrometric technologies. In this session, we would like to discuss how mass spectrometry contributes to the front lines of various omics sciences as well as structural biology fields. In addition, we want to also discuss the next-generation mass spectrometry for protein analysis. We will call for papers in a wide range of subjects related to protein and proteomics research in order to share the latest knowledge and discuss future prospects.
■Keywords
Proteomics, Post-translational modification, Protein activity, Structural biology
Session No.2
■Session No
1B-O2
■Title
Environmental dynamics of femto-level isotopes with Accelerator Mass Spectrometry 2
■Organizer
Hiroyuki MATSUZAKI (Univ Tokyo) / Yasuto MIYAKE (RIKEN)
■Scope
The term “Femto-level isotopes” means extremely rare isotopes of which the isotopic ratio to the stable isotope reaches 1E-15 order. They are typically produced by the interaction of the cosmic-rays and artificial nuclear reaction, mainly fission. Femto-level isotopes take important role in the analysis of paleo-environment/climate change, serve as tracers for atmosphere/ocean circulation. Femto-level isotopes are also good indicators for the definition of the “anthropocene” geological era in which human activity actually affects the environment. We held a similar session in two years ago. This session surveys the achievements both in technical developments and scientific research since the previous session and prospects the future direction.
■Keywords
Accelerator Mass Spectrometry, Cosmic rays, nuclear fission, femto-level isotopes, environmental dynamics, anthropocene
Session No.3
■Session No
1C-O3
■Title
MS session with ambitious researcher
■Organizer
Shu TAIRA (Fukushima Univ) / Shunsuke Tamura (DHC Corporation)
■Scope
This session will accept wide field in MS. Young means below.Young scientists who (1) are dedicated to enhancing scientific and technology through the mass spectrometry, (2) want to tell us originality and sense in own research and (3) make the academic record for own future.
Session No.4
■Session No
2A-O4
■Title
Emerging technologies and applications in mass spectrometry imaging
■Organizer
Masaya IKEGAWA (Doshisha Univ) / Yasuhide NAITO (GPI)
■Scope
Mass spectrometry imaging (MSI) is a rapidly developing area of research that attracts researchers from numerous fields including instrumentation development, drug discovery, clinical research, biochemistry, pathology, forensics, and agricultural sciences. This session on mass spectrometry imaging with a variety of ionization method will be discussion on the progress of the technology and its application. Our session will bring together researchers from multiple fields to discuss key challenges, innovative developments, and emerging applications in mass spectrometry imaging.
■Keywords
Mass spectrometry imaging (MSI), Instrumentation, Desorption Ionization, clinical research, biochemistry, pathology, forensics, agricultural sciences
Session No. 5
■Session No
2B-O5
■Title
Fundamentals of acquisition, analysis, and sharing of mass spectral data
■Organizer
Jun AOKI (Osaka Univ) / Fumio MATSUDA (Osaka Univ)
■Scope
This session deals with fundamentals of acquisition, analysis, and sharing of mass spectral data. We will call for papers including an introduction of the state-of-art technologies as well as future directions, challenges, and fundamentals of mass spectral technologies.
■Keywords
Fundamentals, Informatics, MassBank
Session No.6
■Session No
2A-O6
■Title
Multidisciplinary session for internationalization of MSSJ
■Keynote
Kwan Pyo KIM (Kyurg Hee Univ) / Yoshinao WADA (OWCH)
■Organizer
Masahiro MIYASHITA (Kyoto Univ) / Yasushi ISHIHAMA (Kyoto Univ) / Shuichi SHIMMA (Osaka Univ)
■Scope
This session is dedicated for promoting the internationalization of MSSJ. All presentations and discussions will be provided in English. We will call for papers in a wide range of research subjects related to mass spectrometry. We are especially looking forward to participation from overseas.
■Keywords
multidisciplinary, international, Asia/Oceania
Session No.7
■Session No
2C-O7
■Title
Mass spectrometry in qualitative and quantitative analysis of natural and food compounds
■Organizer
Masahiro MIYASHITA (Kyoto Univ) / Takeshi ARA (Kyoto Univ)
■Invited
Haruya TAKAHASHI (Kyoto Univ)
■Scope
Natural compounds often have unique structure and biological activity, which have been useful as a lead compound for development of drugs and agrochemicals. Foods also contain many functional components, whose structural analysis and quantitation is important for evaluation of its functionality. Mass spectrometry has been played a crucial role in both qualitative and quantitative analysis of natural compounds including food components. However, it is still difficult to determine structures of unknown compounds only by mass spectrometry, which will be facilitated by development of spectral database and prediction software. In this session, we will focus on the mass spectrometric analysis of natural compounds including food components, and discuss novel techniques, technologies and software to contribute to the advancement of this research field.
■Keywords
low-molecular-weight compound, structural determination, fragmentation, bioactivity, database
Session No.8
■Session No
2B-O8
■Title
Structure / composition analysis of industrial materials by mass spectrometry
■Organizer
Hideya KAWASAKI (Kansai Univ) / Shinya KITAGAWA (Nagoya Inst Technol)
■Scope
The focus of this symposium is the application of mass spectrometry (MS) for functional materials such as (co)polymer, surfactant, and organic/inorganic nanomaterials. Since mass spectrometry is recently used for materials/structural analysis in industrial and material sciences, the meeting will provide an opportunity to share their data and methods, learn those from their colleagues and discuss the future direction. Some of the key issues on MS for functional materials that have been addressed are listed as the follows: i) ESI, MALDI, and new ionization methods including DESI, DART, and SALDI, ii) Detailed structural analysis by high-Resolution MS and MS/MS, iii) pyrolysis and separation methods such as GC, LC, and SEC, iv) imaging mass spectrometry.
■Keywords
Polymer, surfactant, and materials, Ionization, Imaging, Data alaysis
Session No.9
■Session No
2C-O9
■Title
Molecular science using mass spectrometry-based techniques
■Organizer
Akimasa FUJIHARA (Osaka Pref Univ) / Keijiro OHSHIMO (Tohoku Univ)
■Invited
Kiyokazu FUKE (Toyota Phys Chem Res Inst)
■Scope
Mass spectrometry utilizes physical and chemical processes such as ionization, ion-molecule reaction, atomic and molecular collision, and fragmentation. Mass spectrometry-based techniques such as ion mobility spectrometry and laser spectroscopy of gas-phase ions play important roles in the fields of molecular science. This session will focus on both molecular science using mass spectrometry-based techniques and mass spectrometry using physical and chemical processes.
■Keywords
Ionization, Ion-molecule reaction, Atomic and molecular collision, Fragmentation
Session No.10
■Session No
3A-O10
■Title
Mass spectrometer for practical use in clinical and drug discovery
■Organizer
Daisuke SAIGUSA (Tohoku Univ) / Masayoshi SAITO (Mitsubishi Tanabe Pharma Corp)
■Keynote
Kei TAKASE (Tohoku Univ)
■Scope
Mass spectrometry has been applied on the experiment of drug discovery based on the accurate determination technology with the sensitive and selective analysis. It is also suitable for the analysis of clinical samples and contributes to the analyses for pharmacokinetics and the variation of endogenous metabolites. Recently, mass spectrometry has been improved as the practical technology in clinical region with concerning the microbial environment. We would like to discuss about the contribution of mass spectrometry in the future study of life science, and practical use for clinical study beside of the patient and the diagnostic examinations.
■Keywords
Clinical, Drug discovery, microbiome, metabolome, biomarker
Session No.12
■Session No
3C-O12
■Title
Frontier in Earth and Space Science developed by the advanced isotopic analysis
■Organizer
Masaharu TANIMIZU (Kwansei Gakuin Univ) / Teruyuki MARUOKA (Tsukuba Univ)
■Keynote
Shinya SHODA (Nara National Research Institute for Cultural Properties)
■Scope
Isotopic analysis is a clue to decipher the origin and evolution of the Solar system. The scope of “Isotope session” of Mass spectrometry conference in 2020 is to cover a variety of topics in Earth and Space sciences based on the advanced isotopic analysis and to enhance mutual understanding of the past and/or on-going processes of the Earth and it's surface environment.
■Keywords
Isotope anomaly, Isotope variation, Nuclear Physics, Earth and Planetary Science, Environmental Science
Session No.13
■Session No
3A-O13
■Title
Current status and future challenges of non-targeted metabolomics
■Organizer
Yoshihiro IZUMI (Kyushu Univ) / Akiyoshi HIRAYAMA (Keio Univ)
■Scope
In recent years, more than 1000 metabolite peaks have been detected in various biological samples because of the rapid development of high-resolution mass spectrometry and data mining techniques. However, only approximately 10% of metabolites can be identified in the detected peaks. Therefore, it is necessary to develop a methodology that enables structure estimation of metabolite peaks obtained by non-target metabolomic analysis. Furthermore, it is important to proceed with structure estimation (identification) of metabolites that can be candidates for new bioactive metabolites or biomarkers among unknown metabolites. In this session, we would like to introduce the current state of structure estimation methods for unknown metabolites by mass spectrometry and discuss future issues.
■Keywords
Non-targeted metabolomics, Activity metabolomics, Structural estimation, High-resolution mass spectrometry
Session No.14
■Session No
3B-O14
■Title
Mass spectrometry for analyzing biological macromolecules
■Organizer
Kentaro ISHII (Osaka Univ) / Kazumi SAIKUSA (AIST)
■Scope
Biological macromolecules have been analyzed by mass spectrometry (MS) at the level of fragmented-peptide for a long time. Now even supramolecular complexes such as a protein complex and a virus can be analyzed conserving inter-subunit interactions (native MS, ion-mobility MS, charge-detection MS). Moreover, hydrogen-deuterium exchange MS (HDX-MS) and MS conjugated with chemical modifications are performed to determine a protein-protein interface. Meanwhile, in the field of biologics represented by therapeutic antibodies, a multi-attribute method primarily based on peptide mapping MS was proposed for the quality control. In the near future, various conventional methods used for biologics quality control might be replaced with MS. New methodologies based on MS have been developed, and as a result, targets have been widened. In this session, we will discuss the structural information and methods in the current mass spectrometry of biological macromolecules.
■Keywords
Biological macromolecule, interaction, peptide mapping, native MS, HDX-MS, ion-mobility, chemical modification, post-translational modification, multi-attribute method, biologics
Session No.15
■Session No
3C-O15
■Title
Environmental mass spectrometry
■Organizer
Hirokazu TAKANASHI (Kagoshima Univ) / Atsushi YAMAMOTO (Tottori Univ Env Stud)
■Scope
In a research field of environmental analysis or environmental protection technology development, trace pollutant determination in complex matrix are needed. In another field of exploratory research into emerging contaminants or non-targeted analysis, determination of molecular formulae, elucidation of chemical structures, and database-matching of targeted molecules are needed. Mass Spectrometry (MS) is one of the promising ways to achieve these: its high detection sensitivity and compatibility with various separation techniques enabled itself to prevail in chemical engineering. On the other hand, its prevalence in research and development is still in progress and further communication among researchers is needed, therefore, the objective of this session is to discuss and share actual applications of MS to research and development among participants.
■Keywords
simultaneous analysis, non-targeted screening, targeted screening, structural elucidation

Poster Presentations

Day 1 Monday, May 11 [Program]
Day 2 Tuesday, May 12 [Program]
Day 3 Wednesday, May 13 [Program]

Workshops

Day 3 Wednesday, May 13 [Program]

Workshop Overview
■Session No
3B-O11
■Title
Issues and solutions in quantitative analysis using LC / MS
■Organizer
Futoshi SATO (Nihon Waters) / Takeshi SERINO (Agilent)
■Invited
Naoki SUGIMOTO (Natl Inst Health Sci)
■Scope
LC / MS is used for quantitative analysis in various fields, but requirements for quantitative analysis, for example the precision, sensitivity, dynamic range, and number of target compounds, differ depending on the field. As a result, method validation such as matrix effect, robustness, and reproducibility, as well as the selection and handling of reference materials and internal standards that are the basis for quantitative values are different.
This session will focus on routine quantitative analysis and share issues and solutions. We will have three invited speakers talks, two speakers from pharmaceutical and food / environmental analysis as representative fields for quantitative analysis, and another one speaker on standard substances that are the basis for quantitative analysis. After that it will be followed by general discussion including participants.
■Keywords
Quantitative analysis, matrix effect, method validation, robustness, reference material