The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Workshops

Luncheon Seminars (Day1, Day2, Day3)

Oral Sessions

Day 3, May 13（Wed.）　16:10-16:30　Room A (Main Hall)

3A-O13-1610　　PDF

Urinary biomarker discovery of nephrotic syndrome by metabolomics

(1Keio Univ., 2Nagoya Univ.)
oAkiyoshi Hirayama1, Shin-ichi Akiyama2, Shoichi Maruyama2, Tomoyoshi Soga1

The definitive diagnosis of nephritis or nephrotic syndrome currently requires a renal biopsy, which is an invasive procedure with bleeding risk. Hence, the development of a non-invasive diagnostic method that uses blood or urine samples instead of biopsy is of great clinical value. In this study, urine samples from 274 nephrotic patients were analyzed using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF-MS). As a result of the metabolomic analysis, 220 metabolite peaks were detected in the urine of nephrotic patients and 127 of those were identified. We further conducted a logistic regression analysis that combines multiple metabolites in order to discriminate from seven types of nephrotic diseases and found that some diseases could be distinguished with high accuracy.