Oral Sessions
- Day 3, May 13（Wed.） 15:30-15:50 Room A (Main Hall)
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3A-O13-1530 PDF
Challenges of MS-DIAL platform for mass spectrometry data processing
Advances in computational mass spectrometry are essential to deepen the understanding of metabolisms and to standardize metabolomics and lipidomics data processing workflows. Nowadays, two techniques, i.e. GC-MS based metabolomics and LC-MS/MS based lipidomics are very preferable approach in biology owing to the fully standardized workflow from the instrumentation till the output of data analysis result. On the other hand, there are still several drawbacks for the profiling of hydrophilic metabolites, natural products, and exposome compounds in the lack of comprehensive annotation pipeline and standardized protocol. As an example of a ‘great-success’ procedure, the current activity in lipidomics standard initiative (LSI) is highlighted with the activity of MS-DIAL platform supporting the LSI nomenclature and quantification system of lipids: the lipidomics output is finally described in the common output format mztab-M (Tsugawa H. et al. bioRxiv 2020). Next, the procedure is compared with that of a natural product study (Tsugawa H. et al. Nature Methods 2019) providing a ‘current methodology’ for comprehensive natural product profiling. Finally, the future perspective especially regarding to MS-DIAL platform is highlighted.