The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Workshops

Luncheon Seminars (Day1, Day2, Day3)

Poster Presentations

Day 1, May 11（Mon.）　　Poster (1008/09)

1P-42（1C-O3-1715）　　PDF

Mass Spectrometry Based Investigation of Photobleaching Coefficient of Protoporphyrin IX Used in Photodynamic Diagnosis and Therapy of Cancer

(1Grad. School of Eng., Osaka Univ., 2Grad. School of Front. Biosci., Osaka Univ., 3MEI Center, Osaka Univ.)
oOgbonna Sochi1, Hisanao Hazama1, Kunio Awazu1,2,3

Photobleaching is one of the phenomena that hinders the effectiveness of photodynamic diagnosis and therapy (PDD/PDT); a cancer diagnosis and treatment technique. We used electrospray ionization mass spectrometry to investigate the photobleaching coefficient β during PDD/PDT. Fluorescence-based investigation of the photobleaching under the same conditions was carried out, and the obtained results were compared with the mass spectrometry-based β value. Variations in the β values from the two investigations were observed, although both β values were within the literature range.