Oral Sessions
- Day 1, May 11（Mon.） 17:10-17:30 Room A (Main Hall)
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1A-O1-1710 PDF
Chemoproteomic platforms to identify target proteins of bioactive metabolites
Small-molecule metabolites including bioactive lipids play central roles in controlling physiology and/or pathophysiology, where their biological functions often arise from interactions with target proteins. While identifying direct protein targets of bioactive small-molecules is critical to understand their biological functions, their specific interactions with the proteome still remain poorly defined. Chemoproteomics has arisen as a powerful technology that enables global identification of protein targets of bioactive small-molecules. There have been a large number of chemical probes developed in recent years. Especially, alkyne-functionalized probes that can be coupled to azide-containing analytical handles by click chemistry are powerful tools for global identification of protein targets. In the presentation, our recent chemoproteomics studies in which we used alkyne-functionalized probes for target identification of small-molecule metabolites will be introduced.